Programme 03 · Research
Pancreatic Neuropathy & Pain
Where does pancreatic pain come from?
The question
Pain in pancreatic disease is often refractory to treatment. We ask which changes in nerves and their environment trigger and sustain it.
Our approach
We study neural remodelling and neurogenic inflammation in human tissue and in disease models, and test analgesic approaches preclinically.
What we have learned
Nerves in the diseased pancreas change structurally: they become denser and hypertrophic, and their remodelling relates to pain severity. We have also identified neuro-immune mediators of pain.
Where we are going
The aim is to develop targeted pain therapies from these mediators that go beyond symptom control.
Publications
Work from this programme
DissertationTU Munich — doctoral thesis, summa cum laude
Neural remodeling and neuronal plasticity in pancreatic cancer and chronic pancreatitis
Demir IE · Doktorvater: Univ.-Prof. Dr. H. FriessFunding
