Principal Investigator · Surgeon-Scientist

Prof. Dr. Dr. Ihsan Ekin Demir

Portrait of Prof. Dr. Dr. Ihsan Ekin Demir
Prof. Dr. Dr. Ihsan Ekin Demir© TUM University Hospital

Ekin Demir is a surgeon-scientist at TUM University Hospital whose work bridges pancreatic surgery, cancer neuroscience, pain research and translational oncology. His group investigates how neural signalling shapes pancreatic cancer, neural invasion and pancreatic pain, with the goal of translating mechanistic discoveries into new therapeutic strategies.

His path through medicine led via Heidelberg, Ankara, St. Louis, Worcester and Munich. What stayed constant across those stations is the question of why a disease takes the course it does. In pancreatic cancer that question led to the nerves — to a tissue that plays a far more active role in the tumour than was long assumed.

Since 2021 the Else Kröner Clinician Scientist Professorship has allowed clinical and scientific work to be combined on a planned basis. That structure is the reason an observation at the specimen could grow into a research programme.

Neural invasionPancreatic neuropathyCancer neuroscienceClinician Scientist
Career

Positions

since 2021
Else Kröner Clinician Scientist Professorship
“Translational Pancreatic Surgery”, TUM
since 2019
Senior Attending Surgeon · Head of the Pancreatic Research Laboratory
Department of Surgery, TUM University Hospital
since 2016
Board-certified visceral surgeon
Certified 3 August 2016
since 2009
Resident, Department of Surgery
TUM University Hospital (Univ.-Prof. Dr. H. Friess)
2003 – 2009
Medical studies and state examination
Heidelberg, TU Munich, Hacettepe (Ankara), Washington University in St. Louis, University of Massachusetts
Recognition

Awards and appointments

2025ERC Consolidator Grant for SYNAPSE-ON-CANCER, European Research Council
2021Else Kröner Clinician Scientist Professorship, Else Kröner-Fresenius-Stiftung
—Rising Star Award, United European Gastroenterology (UEG)
—Dr. med. and Ph.D., both summa cum laude, TUM
Qualification

Doctorates

Dr. med. · summa cum laude

“Neural remodeling and neuronal plasticity in pancreatic cancer and chronic pancreatitis” · Supervisor: Univ.-Prof. Dr. H. Friess

Ph.D. · summa cum laude

“Transcriptional and functional characterization of the first neuro-invasive, genetically engineered mouse model of pancreatic cancer” · Medical Life Science and Technology programme, TUM

Publications

Selected work

2025
Original ArticleCancer Cell

Sensory neurons drive pancreatic cancer progression through glutamatergic neuron-cancer pseudo-synapses

Ren L, Liu C, Çifcibaşı K, … Demir IE
2023
Original ArticleJournal of Clinical Investigation

Phenotype screens of murine pancreatic cancer identify a Tgf-α-Ccl2-paxillin axis driving human-like neural invasion

Wang X, Istvanffy R, Ye L, … Demir IE
2020
Original ArticleClinical Cancer Research

Neoadjuvant Therapy Remodels the Pancreatic Cancer Microenvironment via Depletion of Protumorigenic Immune Cells

Mota Reyes C, Teller S, Muckenhuber A, … Demir IE
2017
Original ArticleProceedings of the National Academy of Sciences (PNAS)

Early pancreatic cancer lesions suppress pain through CXCL12-mediated chemoattraction of Schwann cells

Demir IE, Kujundzic K, Pfitzinger PL, … Ceyhan GO
2015
ReviewNature Reviews Gastroenterology & Hepatology

Neural plasticity in pancreatitis and pancreatic cancer

Demir IE, Friess H, Ceyhan GO
All publications
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