Translational Models & Therapeutic Targeting

Many findings from cell culture and animal models do not survive translation into the clinic. We ask which of our mechanisms hold in the human system.

As a surgically led group we work directly with human tissue from the operating room: organotypic cultures, neuronal co-cultures and in vivo models bridge mechanism and application.

The established 3D and co-culture models allow neural invasion and nerve–tumour signalling to be measured under controlled conditions — on the material of the disease itself.

We are expanding the model platform to prioritise candidates from all programmes under comparable conditions.